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Chemically Modified Insulin Is Available More Rapidly

November 14, 2016

Insulin retains its efficacy but is available more rapidly to the organism when a hydrogen atom is replaced by an iodine atom. Markus Meuwly, Krystel El Hage, Vijay Pandyarajan and co-workers at the University of Basel undertook quantitative atomic-level simulations of 3-I-TyrB26-insulin to predict its structural features and (ii) tested these predictions by X-ray crystallography. Inspired by quantum chemistry and molecular dynamics, such “halogen engineering” promises to extend principles of medicinal chemistry to proteins.
Insulin is formed in the pancreas and regulates the blood glucose level. In the body it is stored as a zinc-bound complex of six identical molecules, called a hexamer. However, the physiologically active form is a single insulin monomer. Only when the body requires insulin the hexamer divides into monomers available for blood sugar regulation. Researchers attempt to control this disassembly process by developing artificial insulin preparations, in order to optimize clinical treatment of diabetes mellitus. By means of chemical modifications, the release and availability of insulin can be improved. One possible approach is to strategically replace individual atoms in a targeted manner. This results in what is known as an insulin analog, which differs from natural insulin in both structure and properties.
The team led by Professor Markus Meuwly from the Department of Chemistry at the University of Basel has investigated this process in collaboration with researchers from the USA and Australia. The researchers exchanged a single hydrogen atom by an iodine atom which modulates intermolecular interactions that resulted in more rapid insulin disassembly and release. Introducing the iodine atom improved the insulins’ availability, while the affinity for the insulin receptor and the biological function remained unchanged when compared to the natural hormone. These advantageous properties were first predicted by a combination of quantum chemistry and molecular dynamics simulations. In a next step, the stability changes of the chemically modified insulin were directly probed by using crystallographic and nuclear magnetic resonance experiments which confirmed the computations.

The use of halogen atoms is a promising approach for compound optimization in medicinal chemistry. The results obtained for iodinated insulin demonstrate that the concept of chemical modification has also great potential in the field of protein engineering. A future clinical application of the insulin analog, which differs from natural insulin by only a single atom, is quite conceivable.

Binding of the insulin analog (green) to the receptor (light blue). The receptor’s surface is shown in transparent gray.

Several scientific and medical website reported on the results:
Reference: El Hage, K., V. Pandyarajan, N. B. Phillips, B. J. Smith, J. G. Menting, J. Whittaker, M. C. Lawrence, M. Meuwly and M. A. Weiss (2016). Extending Halogen-Based Medicinal Chemistry to Proteins: Iodo-Insulin as a Case Study. J. Biol. Chem. (10.1074/jbc.M116.761015) El-Hage-2016 (2.42 MB).
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