Forthcoming Events

11.07.2022 - 15.07.2022, Celeste Hotel, on UCF main campus, Orlando, Florida
05.09.2022 - 09.09.2022, Iseolago hotel, Iseo, Italy.

News

MUST2022 Conference- succesfully concluded
New scientific highlights- by MUST PIs Chergui and Richardson
FELs of Europe prize for Jeremy Rouxel- “Development or innovative use of advanced instrumentation in the field of FELs”
Ruth Signorell wins Doron prizefor pioneering contributions to the field of fundamental aerosol science
New FAST-Fellow Uwe Thumm at ETH- lectures on Topics in Femto- and Attosecond Science
International Day of Women and Girls in Science- SSPh asked female scientists about their experiences
New scientific highlight- by MUST PIs Milne, Standfuss and Schertler
EU XFEL Young Scientist Award for Camila Bacellar,beamline scientist and group leader of the Alvra endstation at SwissFEL
Prizes for Giulia Mancini and Rebeca Gomez CastilloICO/IUPAP Young Scientist Prize in Optics & Ernst Haber 2021
Nobel Prize in Chemistry awarded to RESOLV Member Benjamin List- for the development of asymmetric organocatalysis
NCCR MUST at Scientifica 2021- Lightning, organic solar cells, and virtual molecules
#NCCRWomen- NCCR MUST celebrates 50 years women’s right to vote in Switzerland
Kick-Off dynaMENT Mentoring for Women in Natural Sciences- with Ursula Keller as plenary speaker

Dynamics and mechanism of a light-driven chloride pump

February 2, 2022

(published in Science)
Biological pumps that use retinal isomerization to move protons across a membrane have been studied extensively, but the mechanisms involved in moving chloride ions, which have both a different charge and different coordination requirements, are less well understood. Mous et al. combined time-resolved x-ray crystallography, spectroscopy, and computational simulations to generate a molecular movie of chloride transport through a chloride-pumping halorhodopsin. Ion uptake from the extracellular environment is supported by interactions with the retinal, and transport through a space generated by retinal isomerization occurs within about 1 microsecond of excitation. Release of chloride and blockage of backward flow is mediated by a salt bridge that forms an electrostatic gate at the intracellular face. These insights are important for understanding ion transport in these pumps, which are important tools for optogenetic silencing of neurons. —MAF

 
Reference: Mous, S., Gotthard, G., Ehrenberg, D., Sen, S., Weinert, T., Johnson Philip, J.M., James, D., Nass, K., Furrer, A., Kekilli, D., Ma, P., Brünle, S., Casadei Cecilia, M., Martiel, I., Dworkowski, F., Gashi, D., Skopintsev, P., Wranik, M., Knopp, G., Panepucci, E., Panneels, V., Cirelli, C., Ozerov, D., Schertler, G., Wang, M., Milne, C., Standfuss, J., Schapiro, I., Heberle, J., and Nogly, P. (2022). Dynamics and mechanism of a light-driven chloride pump. Science, eabj6663 (10.1126/science.abj6663)

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