Forthcoming Events

24.01.2018 - 26.01.2018, DESY Hamburg
04.02.2018 - 09.02.2018, Hotel Galvez, 2024 Seawall Boulevard, Galveston, TX, US
13.02.2018 - 15.02.2018, Hilton New Orleans Riverside in New Orleans, LA, USA


GAP-Biophotonics with Jean-Pierre Wolf-visited by the Grand Conseil of Geneva
ERC Consolidator Grant for Hans Jakob WörnerAttosecond X-ray spectroscopy of liquids ...
ERC Consolidator Grant for Fabrizio CarboneVisualizing the Conformational Dynamics of Proteins ...
Swiss national 'Future Day' offered children a glance into their possible professional futures
The world's shortest laser pulse- pulse duration of 43 attoseconds (Hans Jakob Wörner)
Sicherer durchs Gewitter fliegen- flying safely through lightning (Jean Pierre Wolf)
Successful Gender and Science Meeting 2017- 80 participants, lively discussions, and inspiring talks, news item on D-PHYS
ERC Starting Grant for Ulrich LorenzVisualizing the Conformational Dynamics of Proteins ...
Ambizione awards for three current and former MUST researchers- Axel Schild, Arianna Marchioro and Dmitry Momotenko
OSA - Women of Light: A Special Program for Women in Optics, with Ursula Keller

ERC Starting Grant for Ulrich Lorenz

Visualizing the Conformational Dynamics of Proteins by Time-Resolved Electron Microscopy

Ulrich Lorenz is a junior PI in MUST. Since March 1, 2016, he has an Assistant Professorship at EPFL that is sponsored by the Swiss National Science Foundation. On June 1, he was appointed Tenure Track Assistant Professor. He studied Chemistry at the University of Würzburg, straying very briefly into Metal Organic Chemistry, before discovering his interest in Molecular Physics. During his Ph.D. in the group of Prof. Thomas Rizzo at EPFL, he worked on the spectroscopy and dynamics of cryogenic molecular ions in the gas-phase, which included a fair share of instrument development. For his postdoc in the group of Prof. Ahmed Zewail at Caltech, he switched to the field of Time-resolved Electron Microscopy, studying the dynamics of nanoscale systems.

A summary of his ERC-project: "The function of many proteins involves large-amplitude domain motions that occur on a timescale of microseconds to millisecond. In the absence of tools to directly observe these dynamics, our understanding of the function of proteins is necessarily incomplete and must frequently rely on extrapolation from known static structures. The project involves the implementation of real-time imaging of single particle dynamics in liquid phase with both microsecond time resolution as well as near-atomic spatial resolution. The experimental approach builds on several recent technological advances, namely the advent of Time-Resolved (“Four-Dimensional”) Electron Microscopy, in-situ Electron Microscopy, and direct electron detection cameras, which are combined with established single-particle reconstruction techniques in cryo-Electron Microscopy. Visualizing the conformational dynamics of proteins will fundamentally advance our understanding of these nanoscale machines and has the potential to greatly benefit biomedical applications."

Download (67 KB)
NCCR MUST Office : ETHZ IQE/ULP-HPT H3 | Auguste-Piccard-Hof 1 | 8093 Zurich | E-Mail | +41 44 633 36 02
The National Centres of Competence in Research (NCCR) are a research instrument of the Swiss National Science Foundation