Forthcoming Events

05.09.2022 - 09.09.2022, Iseolago hotel, Iseo, Italy.


MUST2022 Conference- a great success!
New scientific highlights- by MUST PIs Wörner, Chergui, and Richardson
FELs of Europe prize for Jeremy Rouxel- “Development or innovative use of advanced instrumentation in the field of FELs”
Ruth Signorell wins Doron prizefor pioneering contributions to the field of fundamental aerosol science
New FAST-Fellow Uwe Thumm at ETH- lectures on Topics in Femto- and Attosecond Science
International Day of Women and Girls in Science- SSPh asked female scientists about their experiences
New scientific highlight- by MUST PIs Milne, Standfuss and Schertler
EU XFEL Young Scientist Award for Camila Bacellar,beamline scientist and group leader of the Alvra endstation at SwissFEL
Prizes for Giulia Mancini and Rebeca Gomez CastilloICO/IUPAP Young Scientist Prize in Optics & Ernst Haber 2021
Nobel Prize in Chemistry awarded to RESOLV Member Benjamin List- for the development of asymmetric organocatalysis
NCCR MUST at Scientifica 2021- Lightning, organic solar cells, and virtual molecules
#NCCRWomen- NCCR MUST celebrates 50 years women’s right to vote in Switzerland

Fast bioimaging with an X‐ray laser

Date Fr, 20.04.2012 - Di, 22.02.2022
Time 11:15 am
Speaker John C.H.Spence, ASU Physics and LBNL, USA
Location PSI, WHGA/001
Program P S I C o l l o q u i u m

I will review our* recent experiments with the first hard X‐ray laser at SLAC near Stanford, the LCLS. These have included snap‐shot imaging from membrane protein nanocrystals and viruses, and the first pump‐probe experiments on Photosystem 1 ‐ ferredoxin using a liquid jet sampledelivery system of novel design. Our aim is to record movies of molecular machines at work, using femtosecond X‐ray pulses so brief that they terminate before radiation damage commences. New phasing methods for protein nanocrystals and the extraction of structure factors by our Monte‐Carlo method will be reviewed. Recent work using angular correlation functions to recover molecular images from the correlated fluctuations in snap‐shot diffraction patterns from many randomly‐oriented molecules in solution will also be outlined. The prospects for dynamic snapshot chemical imaging using mixing jets will also be described, and a new method based on the Kapitza‐Dirac effect which uses a laser as a Zernike phase plate for electron microscopy. Finally, we consider the prospects for using fast electron beam pulses instead of X‐rays for molecular movies.

* Chapman et al Nature 470, 73 (2011).
Spence et al Rep. Prog. Phys. (2012).
Fromme and Spence, Curr. Opin. Struct. Biol. 21, 509 (2011).
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