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Harmonic nanoparticles for nonlinear imaging and DNA photo-interaction

Date Do, 17.04.2014 - Do, 17.04.2014
Time 10.15
Speaker Dr. Luigi Bonacina, GAP Biophotonics, University of Geneva
Location Universität Bern, Institut für Angewandte Physik, Gebäude exakte Wissenschaften, Hörsaal B116, Sidlerstrasse 5, 3012 Bern
Program The term harmonic nanoparticles designate a family of inorganic nanometric crystals (size < 100 nm) of different materials (KNbO3, BiFeO3, LiNbO3, KTP, ...) sharing the characteristic of noncentrosymmetric structure. This property determines their large nonlinear optical efficiency, and, in fact, in the last years they have been mostly investigated as localized sources for second harmonic generation. After introducing this approach and comparing it with respect to other nanoparticles-based labelling strategies (quantum dots, upconversion NPs), I will highlight some recent applications in the field of (multi-photon) imaging and optical detection of biological samples together with NPs-mediated photo-interaction with cellular DNA.

L. Bonacina, Nonlinear Nanomedecine: Harmonic Nanoparticles toward Targeted Diagnosis and Therapy, Mol. Pharmaceutics, 10(3) 783-792 (2013) D. Staedler et al., Deep UV generation and direct DNA photointeraction by harmonic nanoparticles in labelled samples, Nanoscale 6, 2929 (2014)
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