Forthcoming Events

05.09.2022 - 09.09.2022, Iseolago hotel, Iseo, Italy.


MUST2022 Conference- a great success!
New scientific highlights- by MUST PIs Wörner, Chergui, and Richardson
FELs of Europe prize for Jeremy Rouxel- “Development or innovative use of advanced instrumentation in the field of FELs”
Ruth Signorell wins Doron prizefor pioneering contributions to the field of fundamental aerosol science
New FAST-Fellow Uwe Thumm at ETH- lectures on Topics in Femto- and Attosecond Science
International Day of Women and Girls in Science- SSPh asked female scientists about their experiences
New scientific highlight- by MUST PIs Milne, Standfuss and Schertler
EU XFEL Young Scientist Award for Camila Bacellar,beamline scientist and group leader of the Alvra endstation at SwissFEL
Prizes for Giulia Mancini and Rebeca Gomez CastilloICO/IUPAP Young Scientist Prize in Optics & Ernst Haber 2021
Nobel Prize in Chemistry awarded to RESOLV Member Benjamin List- for the development of asymmetric organocatalysis
NCCR MUST at Scientifica 2021- Lightning, organic solar cells, and virtual molecules
#NCCRWomen- NCCR MUST celebrates 50 years women’s right to vote in Switzerland

Coherent Discrimination of Biomolecules in the Deep UV

Date Do, 22.09.2011 - Do, 22.09.2011
Time 10.15
Speaker Dr. Ariana Rondi, GAP-Biophotonics, University of Geneva
Location Universität Bern, Institut für Angewandte Physik, Gebäude exakte Wissenschaften, Hörsaal B77, Sidlerstrasse 5, 3012 Bern
Program The high sensitivity of fluorescence spectroscopy and the broad range of promising applications enabled by this technique are severely limited by its lack of molecular selectivity. This drawback becomes particularly evident when the identification of cellular endogenous fluorophores is of interest.
To overcome this limitation, our group demonstrated in 2009 that the fluorescence-based identification of two almost identical and highly relevant biomolecules (FMN, RBF) is possible by using the Optimal Dynamic Discrimination (ODD) technique, a two-step photo-excitation scheme implying a phase-tailored UV femtosecond pulse.
During the talk, I will present the work that I have done during my thesis. I will start by providing some general information about femtosecond pulse shaping and closed-loop optimization of molecular photo-dynamics. In particular, I will concentrate on two innovative features we have brought to this field in terms of shaping technology (reflective MEMS shaper) and optimization algorithm (multi-objective approach). I will then show how we extended the ODD technique to the deep UV. We demonstrated discrimination of two amino-acids, opening interesting perspectives for future experiments involving biomolecules of increasing complexity, namely polypeptides and proteins, eventually in a cellular environment.
Download (75 KB)
(75 KB)
NCCR MUST Office : ETHZ IQE/ULP-HPT H3 | Auguste-Piccard-Hof 1 | 8093 Zurich | E-Mail
The National Centres of Competence in Research (NCCR) are a research instrument of the Swiss National Science Foundation