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Measuring tissue scattering by Optical Coherence Tomography

Date Di, 31.05.2011 - Di, 31.05.2011
Time 10.15
Speaker Prof. Ton G. van Leeuwen, Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, Biomedical Photonic Imaging Group, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente
Location Universität Bern, Institut für Angewandte Physik, Gebäude exakte Wissenschaften, Hörsaal A97, Sidlerstrasse 5, 3012 Bern
Program Optical Coherence Tomography allows quantitative measurements of the scattering coefficient μs. We show that μs is related to tissue structures and disease, e.g. due to increased proliferation (tumors) and cell death (apoptosis and necrosis). Still, measurements are influenced by multiple scattering effects and concentration dependent scattering effects, which both lead to an underestimation of μs . Their contribution to the OCT-measured μs was investigated at 600, 800, 1300 and 1600 nm on Intralipid dilutions. A non-linear increase of μs with concentration was found for all wavelengths. At the higher wavelengths the contribution of multiple scattering is expected to be low. We therefore conclude that concentration dependent scattering effects should be taken into account for quantitative μs measurements.
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