Forthcoming Events

05.09.2022 - 09.09.2022, Iseolago hotel, Iseo, Italy.

News

MUST2022 Conference- a great success!
New scientific highlights- by MUST PIs Wörner, Chergui, and Richardson
FELs of Europe prize for Jeremy Rouxel- “Development or innovative use of advanced instrumentation in the field of FELs”
Ruth Signorell wins Doron prizefor pioneering contributions to the field of fundamental aerosol science
New FAST-Fellow Uwe Thumm at ETH- lectures on Topics in Femto- and Attosecond Science
International Day of Women and Girls in Science- SSPh asked female scientists about their experiences
New scientific highlight- by MUST PIs Milne, Standfuss and Schertler
EU XFEL Young Scientist Award for Camila Bacellar,beamline scientist and group leader of the Alvra endstation at SwissFEL
Prizes for Giulia Mancini and Rebeca Gomez CastilloICO/IUPAP Young Scientist Prize in Optics & Ernst Haber 2021
Nobel Prize in Chemistry awarded to RESOLV Member Benjamin List- for the development of asymmetric organocatalysis
NCCR MUST at Scientifica 2021- Lightning, organic solar cells, and virtual molecules
#NCCRWomen- NCCR MUST celebrates 50 years women’s right to vote in Switzerland

Focal Molography on a Monolithic Brushed-Polymer Layer

Date Fr, 11.12.2015 - Fr, 11.12.2015
Time 16.00
Speaker Dr. Christof Fattinger, Roche Innovation Center Basel
Location ETH Hönggerberg, HCI J7
Program The talk introduces the fundamentals of focal molography and describes the synthesis of molograms on a chip by submicron near-field lithography on a light-sensitive monolithic brushed-polymer layer.
Focal molography, a recent theoretical discovery in biophysics and photo-chemistry, makes biomolecular interactions visible. The molographic biosensor is applicable to all studies in which molecular recognition and binding are of prime interest. Molography transforms chemical contrast into optical contrast by scattering of coherent light at a coherent assembly of molecular interaction sites, termed the “mologram”. Molography discriminates the specific binding to the interaction sites in the mologram from nonspecific bindings to the sensor surface via detection of the coherent signal in the focus of the mologram. We demonstrate the selective and sensitive detection of biomolecules which bind to the recognition sites on the mologram in a complex biological sample. This opens up new perspectives and possibilities in the analysis of noncovalent interactions involving known or unknown biomolecules in complex biological samples and novel ways of performing immunoassays and the development of diagnostic tests.

References:
1. C. Fattinger, Focal Molography: Coherent Microscopic Detection of Biomolecular Interaction, Physical Review X 2014, 4 (3), 13
2. G. Binnig, Coherent signal picks out biomolecular interactions, Physics 7, 84 (2014)
Download (75 KB)
(75 KB)
Link
NCCR MUST Office : ETHZ IQE/ULP-HPT H3 | Auguste-Piccard-Hof 1 | 8093 Zurich | E-Mail
The National Centres of Competence in Research (NCCR) are a research instrument of the Swiss National Science Foundation