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Fast bioimaging with an X‐ray laser

Date Fr, 20.04.2012 - Di, 22.02.2022
Time 11:15 am
Speaker John C.H.Spence, ASU Physics and LBNL, USA
Location PSI, WHGA/001
Program P S I C o l l o q u i u m

I will review our* recent experiments with the first hard X‐ray laser at SLAC near Stanford, the LCLS. These have included snap‐shot imaging from membrane protein nanocrystals and viruses, and the first pump‐probe experiments on Photosystem 1 ‐ ferredoxin using a liquid jet sampledelivery system of novel design. Our aim is to record movies of molecular machines at work, using femtosecond X‐ray pulses so brief that they terminate before radiation damage commences. New phasing methods for protein nanocrystals and the extraction of structure factors by our Monte‐Carlo method will be reviewed. Recent work using angular correlation functions to recover molecular images from the correlated fluctuations in snap‐shot diffraction patterns from many randomly‐oriented molecules in solution will also be outlined. The prospects for dynamic snapshot chemical imaging using mixing jets will also be described, and a new method based on the Kapitza‐Dirac effect which uses a laser as a Zernike phase plate for electron microscopy. Finally, we consider the prospects for using fast electron beam pulses instead of X‐rays for molecular movies.

* Chapman et al Nature 470, 73 (2011).
Spence et al Rep. Prog. Phys. (2012).
Fromme and Spence, Curr. Opin. Struct. Biol. 21, 509 (2011).
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