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Coherent Discrimination of Biomolecules in the Deep UV

Date Do, 22.09.2011 - Do, 22.09.2011
Time 10.15
Speaker Dr. Ariana Rondi, GAP-Biophotonics, University of Geneva
Location Universität Bern, Institut für Angewandte Physik, Gebäude exakte Wissenschaften, Hörsaal B77, Sidlerstrasse 5, 3012 Bern
Program The high sensitivity of fluorescence spectroscopy and the broad range of promising applications enabled by this technique are severely limited by its lack of molecular selectivity. This drawback becomes particularly evident when the identification of cellular endogenous fluorophores is of interest.
To overcome this limitation, our group demonstrated in 2009 that the fluorescence-based identification of two almost identical and highly relevant biomolecules (FMN, RBF) is possible by using the Optimal Dynamic Discrimination (ODD) technique, a two-step photo-excitation scheme implying a phase-tailored UV femtosecond pulse.
During the talk, I will present the work that I have done during my thesis. I will start by providing some general information about femtosecond pulse shaping and closed-loop optimization of molecular photo-dynamics. In particular, I will concentrate on two innovative features we have brought to this field in terms of shaping technology (reflective MEMS shaper) and optimization algorithm (multi-objective approach). I will then show how we extended the ODD technique to the deep UV. We demonstrated discrimination of two amino-acids, opening interesting perspectives for future experiments involving biomolecules of increasing complexity, namely polypeptides and proteins, eventually in a cellular environment.
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