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Focal Molography on a Monolithic Brushed-Polymer Layer

Date Fr, 11.12.2015 - Fr, 11.12.2015
Time 16.00
Speaker Dr. Christof Fattinger, Roche Innovation Center Basel
Location ETH Hönggerberg, HCI J7
Program The talk introduces the fundamentals of focal molography and describes the synthesis of molograms on a chip by submicron near-field lithography on a light-sensitive monolithic brushed-polymer layer.
Focal molography, a recent theoretical discovery in biophysics and photo-chemistry, makes biomolecular interactions visible. The molographic biosensor is applicable to all studies in which molecular recognition and binding are of prime interest. Molography transforms chemical contrast into optical contrast by scattering of coherent light at a coherent assembly of molecular interaction sites, termed the “mologram”. Molography discriminates the specific binding to the interaction sites in the mologram from nonspecific bindings to the sensor surface via detection of the coherent signal in the focus of the mologram. We demonstrate the selective and sensitive detection of biomolecules which bind to the recognition sites on the mologram in a complex biological sample. This opens up new perspectives and possibilities in the analysis of noncovalent interactions involving known or unknown biomolecules in complex biological samples and novel ways of performing immunoassays and the development of diagnostic tests.

1. C. Fattinger, Focal Molography: Coherent Microscopic Detection of Biomolecular Interaction, Physical Review X 2014, 4 (3), 13
2. G. Binnig, Coherent signal picks out biomolecular interactions, Physics 7, 84 (2014)
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