Ursula Keller wins “Swiss Nobel” Marcel Benoist Prize
Farewell: the NCCR MUST ended 
MUST2022 Conference
New scientific highlights
FELs of Europe prize for Jeremy Rouxel
Ruth Signorell wins Doron prize
New FAST-Fellow Uwe Thumm at ETH
International Day of Women and Girls in Science
New scientific highlight
EU XFEL Young Scientist Award for Camila Bacellar,
Prizes for Giulia Mancini and Rebeca Gomez Castillo
Nobel Prize in Chemistry awarded to RESOLV Member Benjamin List
Hans Jakob Wörner invited to give the „New Horizons Solvay Lectures” 
Unusual keynote talk at an international scientific conference
NCCR MUST at Scientifica 2021Radiation Damage and Phasing in Protein Crystallography at X-ray Free-Electron Lasers
| Date | Di, 15.03.2016 | |
| Time | 13.15 | |
| Speaker | Dr. Karol Nass, Max-Planck-Institut, Heidelberg, Germany | |
| Location | OSGA/EG06 (Hörsaal PSI Schulungsgebäude) | |
| Program | Abstract The ultrafast radiation damage process begins with photoionization, followed by impact ionization by photo- and Auger electrons. The ionization of atoms develops with time, ultimately causing lattice disorder and Coulomb explosion of the crystal. Due to very short pulse duration, it has been proposed that diffraction can be recorded before significant structural changes occur. This has been termed “diffraction-before-destruction”. However, achieving sufficient scattering signal for measuring nanocrystals or non-crystalline single particles requires higher power densities than those used in microcrystallography experiments. In order to explore whether undamaged crystal structures can be obtained with higher power densities at the sample, we used two colour x-ray FEL pulses (15 fs) with variable (0-100fs) time delay from the Linac Coherent Light Source (LCLS). These pulses were focused to approximately 100 nm2 to study radiation damage processes in protein crystals in a time-resolved fashion. It is expected that a significant fraction of atoms in the crystal become highly ionized during exposure to the tightly focused x-ray FEL pulse. Indications of global and specific radiation damage and observation of correlated movement of atoms in the structure will be discussed. In addition, de novo phasing approaches and efforts in minimizing the systematic errors will be discussed. 1Karol Nass, 2Sébastien Boutet, 2Andrew Aquila, 1Thomas R.M. Barends, 1R. Bruce Doak, 1Lutz Foucar, 1Mario Hilpert, 2Mark S. Hunter, 2Jason Koglin, 1Gabriela Kovacsova, 2Mengning Liang, 1Christopher M. Roome, 1Robert L Shoeman, 1Ilme Schlichting 1Max-Planck-Institut für Medizinische Forschung, Jahnstraße 29, 69120 Heidelberg, Germany 2Linac Coherent Light Source, SLAC National Accelerator Laboratory, Sand Hill Road, Menlo Park, CA, 94025, USA |
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| Download |  160315 Invitation SwissFEL Seminar (101 KB) |
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