Forthcoming Events

16.12.2021 - 21.12.2021, Honolulu, Hawaii, USA
01.06.2022 - 30.06.2022, Grindelwald, Switzerland
27.06.2022 - 29.06.2022, University College London, UK

News

NCCR MUST at Scientifica 2021- Lightning, organic solar cells, and virtual molecules
#NCCRWomen- NCCR MUST celebrates 50 years women’s right to vote in Switzerland
Kick-Off dynaMENT Mentoring for Women in Natural Sciences- with Ursula Keller as plenary speaker
Four new scientific highlights- by MUST PIs Chergui / Milne / Beaud / Staub, by Wolf / Röthlisberger, by Wörner, and Keller
Photon Science Roadmap- for Research Infrastructures 2025-2028 by the Swiss Photon Community
Proof of concept ERC Grant for Ursula Keller Dual-comb laser driven terahertz spectrometer for industrial sensing (DC-THz)
Majed Chergui - elected to the European Academy of Sciences
Ruth Signorell - elected to the European Academy of Sciences
Farewell and Welcome!Chris Milne leaves for the European XFEL, Camila Bacellar takes over
SY-GAIA expedition - measures aerosols in the North-Atlantic

Investigating Functional Dynamics in Proteins by Novel Multidimensional Optical Spectroscopies in the Ultraviolet

September 2017

Laboratory of Molecular Nanodynamics, EPFL, Visualizing the Conformational Dynamics of Proteins by Time-Resolved Electron Microscopy

The function of many proteins involves large-amplitude domain motions that occur on a timescale of microseconds to millisecond. In the absence of tools to directly observe these dynamics, our understanding of the function of proteins is necessarily incomplete and must frequently rely on extrapolation from known static structures. The project involves the implementation of real-time imaging of single particle dynamics in liquid phase with both microsecond time resolution as well as near-atomic spatial resolution. The experimental approach builds on several recent technological advances, namely the advent of Time-Resolved (“Four-Dimensional”) Electron Microscopy, in-situ Electron Microscopy, and direct electron detection cameras, which are combined with established single-particle reconstruction techniques in cryo-Electron Microscopy. Visualizing the conformational dynamics of proteins will fundamentally advance our understanding of these nanoscale machines and has the potential to greatly benefit biomedical applications.

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The National Centres of Competence in Research (NCCR) are a research instrument of the Swiss National Science Foundation
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